The buccal patch designed in a matrix configuration contains drug, adhesive, and additives mixed together. Mucoadhesive bilayered buccal patches of metoprolol tartarate were formulated using chitosan as the mucoadhesive polymer and the base matrix for the drug. Formulation of unidirectional release buccal patches of. Formulation and evaluation of buccal patches for delivery. Formulation and evaluation of mucoadhesive buccal patches of. Formulation and evaluation of mucoadhesive buccal film of. Design and evaluation of tizanidine buccal mucoadhesive patches and p. The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of pantoprazole which offers an attractive route of administration for systemic drug delivery. The patches were prepared with ionic polymers, sodium carboxymethyl cellulose scmc and chitosan, or nonionic polymers, polyvinyl alcohol pva, hydroxyethyl cellulose hec and hydroxypropylmethyl cellulose hpmc. Buccal adhesive films are new drug delivery system, which are made by using mucoadhesive polymer. Sathish and shayeda abstract patches of cyproheptadine hydrochloride cph which is a sedating antihistamine with antimuscarinic, serotoninantagonist, and calciumchannel blocking action. Mucoadhesive polymers these are the main component for adhesion. They consists of solid matrix nondissolvable or slowly dissolvable. Specific processes include mechanical interlocking, electrostatic, diffusion interpenetration, adsorption.
They can be prepared by two methods solvent casting method direct milling method 32020 31 department of pharmaceutical technology, lj institute of pharmacy, ahmedabad. An approach to prepare buccal patches using chitosan and hpmc polymers jose, jobin, charyulu, r. Formulation and in vitro evaluation of bilayered buccal. Buccal patchesfilms they are long, flat, thin thickness, transparent. The structure of the matrix type design is basically a mixture of the drug with the mucoadhesive matrix. Hpmc 15 cps 1750mg for patch 1 was weighed accurately and added in 15 ml of solvent. Attempts have been made to formulate various mucoadhesive devices including tablets, films, patches, disks, strips, ointments and gels. Apr 10, 20 administering the drug via membrane located below the tongue is called sublingual ddssldds generally called floor of mouth. Ann rose augusthy 1, vipin kv 2, sarath chandran c 2, thushara mv 2, shahin muhammed tk 3. The fresh buccal mucosa is tied on the glass slide, and a mucoadhesive patch is wetted with 1 drop of phosphate buffer ph 6. The patches were evaluated for weight and thickness, content uniformity, surface ph, swelling, in. Though there is ample of work done in this field of mucoadhesive patch development but clinical usage is flimsy. Cydot is an example of a patch technology where the patch adheres to the buccal mucosa for a period of up to 24 hours to slowly release melatonin for normalizing circadian rhythms.
Formulation development and characterization tej pratap singh1, rakesh kumar singh1, jigar n shah2 and tejal a mehta2 1faculty of pharmacy, s. However, buccal patch offer greater flexibility and comfort than the other devices. In this study, mucoadhesive patches were prepared with tamarind gum and hpmc. Preparation of mucoadhesive patches for buccal administration. Jun 09, 2010 the buccal cavity is easily accessible for self medication, and hence it is safe and well accepted by patients, since buccal patches can be very easily administered and even removed from the application site, terminating the input of drug whenever desired. Avoids firstpass hepatic metabolism prochlorperazine brand name oreton,schering buccastem, alternative to enteral tablet department of. Novel drug delivery systems ndds are the system where the man searches for new methods of entry of drugs in to the body in order to show its activity in the body. Buccal methyltestosterone brand namemetandren, ciba.
Novel buccal dosage forms the novel type buccal dosage forms include buccal adhesive tablets, patches, films, semisolids ointments and gels and powders. Buccal patches buccal patch is a nondissolving thin matrix modifiedrelease dosage form composed of one or more polymer films or layers containing the drug andor other excipients. Buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior to placing in contact with buccal mucosa. The patch may contain a mucoadhesive polymer layer which bonds to the oral mucosa, gingiva, or.
Design and evaluation of tizanidine buccal mucoadhesive. P, india, 2nirma institute of pharmacy, nirma university, ahmedabad gujarat india. Polyvinyl alcohol was weighed accurately and dissolved in water to prepare 2%wv. Development of mucoadhesive patches for buccal administration of ibuprofen. A clinical perspective on mucoadhesive buccal drug. Sushma gopal sree dattha institute of pharmacy, sheriguda, ibrahmipatnum, hyderabad abstract the main objective of present study was to design and evaluate the muco adhesive buccal patch. Formulation and characterization of mucoadhesive buccal films of. The results of the study demonstrated that xanthan mucoadhesive buccal patches are potential candidates for controlled biphasic nicotine delivery. Formulation and evaluation of mucoadhesive buccal patches. Mucoadhesive buccal patches containing propranolol hydrochloride were prepared using the solvent casting method. Avoids firstpass hepatic metabolism prochlorperazine brand name oreton,schering buccastem, alternative to enteral tablet department of pharmaceutical technology,41020 lj institute of pharmacy, ahmedabad 52.
The patches were prepared by the solvent casting method. Mucoadhesive buccal patches based on interpolymer complexes. Mucoadhesive bilayered patches for administration of. The ex vivo mucoadhesive force was in the range of 0. The new drug delivery system that have been developed and developing are the mucoadhesive drug delivery systems, drug patches. Design of buccal mucoadhesive patches the different components of buccal mucoadhesive patches are as following. Research paper formulation and evaluation of pimozide buccal mucoadhesive patches biswajit basu1, kevin garala1, thimmasetty j2, 1. Bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin. Mucoadhesive patches containing 10 mg miconazole nitrate were evaluated. Mucoadhesive drug delivery system is a part of controlled delivery system.
Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process. Nicotine was used as a model drug for the characterization of drug release and drug permeation. The important drug properties that affect its diffusion through the patch as well as the buccal include molecular weight, chemical functionality and melting point. Gelatin and polyvinyl pyrrolidone pvp k30 were incorporated into the patches, to improve the film properties of the patches. Glimepiride shows the high in conventional tablet dosage form, which can be terminated by buccal dosage form. Development of mucoadhesive patches for buccal administration. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture absorption as well as for in vitro and in vivo bioadhesion. Formulation, development and invitro evaluation of. Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism. Development of new drug delivery system has been one of the major thrust area of pharmaceuticals these days. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture. Buccal adhesive patches are modified release dosage form that have potential to provide controlled drug delivery from 1 to 24 hrs.
Literature studies on preparation and evaluation of buccal. Moreover, buccal patches provide more flexibility than other drug deliveries. Various natural polymers which can be used in mucoadhesive buccal patches are chitosan, sodium alginate, tragacanth, gelatin and guar gum etc. The sldds is almost similar to the bdds having some more advantages than buccal drug delivery system. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Development of bilayered mucoadhesive patches for buccal. A bioadhesive thcl tablet for buccal delivery has been formulated and evaluated by shanker et al. Original article mucoadhesive bilayer buccal patches of verapamil hydrochloride. Formulation and evaluation of buccal patches for delivery of atenolol article pdf available in aaps pharmscitech 1. Preparation of buccal mucoadhesive controlled drug delivery systems of. The buccal patch designed in a reservoir system contains a cavity for the drug and additives separate from the adhesiveimpermeable backing is applied to control the direction of drugdelivery.
Pdf formulation and evaluation of buccal patches for. Mucoadhesive buccal patch, natural polymer, mucoadhesion. Development of tizanidine hclmeloxicam loaded mucoadhesive. Intestinal mucoadhesive devices for oral delivery of. Formulation and invitro evaluation of mucoadhesive buccal. Research paper formulation and evaluation of pimozide. So buccal mucoadhesive dosage forms like tablets, patches, gels have been extensively reported in literature. Department of pharmaceutics, atmiya institute of pharmacy, rajkot 360005, gujarat state, india. Moreover, it must also exhibit good mucoadhesive strength so that it can be retained in the mouth for a desired duration. The drug containing layer was prepared by using pectin. Formulation and evaluation of a bioadhesive patch for buccal. As such, the mechanical, mucoadhesive, and swelling properties of buccal patches are. An ideal buccal patch should be flexible, elastic and soft yet adequately strong to withstand breakage due to stress from mouth activities.
The main aim of the study was to develop and evaluate mucoadhesive patches of atenolol for the treatment of cardiac diseases. Buccal or sublingual regions within oral cavity can be used for systemic delivery of drugs. Mucoadhesive buccal patches and use of natural polymer in. A piece of porcine buccal mucosa was tied to the open mouth of a glass vial filled completely with. Chitosan, a derivative form of chitin, is a naturally occurring biopolymer and have a large number of pharmaceutical applications. Buccal mucoadhesive patches were prepared using polymer or polymer blends along with the drug and a suitable solvent mixture. Formulation and evaluation of mucoadhesive buccal film of lisinopril.
Aug 06, 2012 formulation and evaluation of mucoadhesive buccal patches of labetalol. New formulation of buccal films containing rizatriptan benzoate rb was prepared by solvent casting method using various concentrations of hydroxypropyl methylcellulose hpmc k4m, polyvinyl alcohol pva, polyethylene oxide peo, glycerol, stevia. Pdf mucoadhesive patches of salbutamol sulphate for. Buccal patches must be flexible, elastic and strong to withstand the mechanical activity inside the mouth. A clinical perspective on mucoadhesive buccal drug delivery. Pdf development of mucoadhesive patches for buccal. Research paper formulation and evaluation of pimozide buccal. New formulation and approach for mucoadhesive buccal film of. Generally factors affecting the sldds are almost similar to factors related with the bdds. The backing membrane was prepared by using sodium alginate. The use of mucoadhesive polymers in buccal drug delivery has a greater application.
Varvandkar1 college of pharmacy, wanadongri, hingna road, nagpur441 110. Yadav2 1dstsms college of pharmacy, solapur, maharashtra 404,india. The new drug delivery systems that have been developed and developing are the mucoadhesive drug delivery systems, drug patches, transdermal patches etc. Transbuccal delivery of chlorpheniramine maleate from.
In this study mucoadhesive buccal patches were prepared. The impermeable backing layer was of ethyl cellulose to ensure a unidirectional drug release. Ppt buccal drug delivery system powerpoint presentation. A free powerpoint ppt presentation displayed as a flash slide show on id. Formulation and characterization of buccal mucoadhesive patch of chlorhexidine gluconate deepak s. The present investigation highlights the formulation and evaluation of mucoadhesive buccal films of ranitidine hydrochloride. Formulation and characterization of buccal mucoadhesive. Sateesh babu abstract mucoadhesive buccal dosage forms are becoming more popular and patient avoidance of first pass metabolism and liver toxicity, etc. Buccal patches films they are long, flat, thin thickness, transparent with high surface area. In this study, carbopol devices were used as a control and compared with e po devices since carbopol is also a good mucoadhesive polymer and is widely used in many mucoadhesive formulations for oral buccal delivery of drugs. The major categories are wetting theory, adsorption theory, diffusion theory, electrostaticic theory, and fracture theory.
Venous blood reaches the heart directly via internal jugular vein. Buccal mucoadhesive tablets buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior to. The surface ph of all the patches c1c7 was near 6 aframian et al. Development and characterization of mucoadhesive buccal patches. Evaluation of zolmitriptan mucoadhesive buccal patches. Mucoadhesive buccal patches of aceclofenac were prepared using different polymers like hydroxypropyl methylcellulose, carbopol 934p, polyvinyl alcohol, polyvinyl pyrrolidone k30, eudragit l100 in various proportion and combinations by solvent casting method.
The study demonstrated that the dosage form was nonirritating and did not cause mucosal damage or irritation upon buccal administration. Formulation and evaluation of buccal patches of diclofenac sodium shubhra pandey abstract. Mucoadhesive buccal film is developed as a promising dosage form, which has prominent advantages because of drug delivery through buccal mucosa. A buccal patch for systemic administration of acyclovir in the oral cavity was. Mucoadhesive buccal patches formulations reported in the literature. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon 889 swelling index the swelling index was measured using the diameter method. Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. Development and characterization of mucoadhesive buccal patches of salbutamol sulphate. Formulation and evaluation of mucoadhesive buccal patch. Mucoashesive buccal films formulated to obtain treatment effectiveness, reduction of drug dose, increase and residence time at the site and to. Abstract the main objective of the present study was to. The prepared buccal patches were evaluated for following properties like weight uniformity, thickness, folding endurance, surface ph, swelling index, invitro residence time, tensile strength, drug content, invitro release study, stability study. The buccal mucoadhesive patches of acetaminophen bpc1 was prepared by solvent casting method using film forming polymers for the patches mentioned in table 1. The tizanidine has first pass metabolism because of this the patient has to take more dose and two to three times in a.
In vitroin vivo correlation of mucoadhesion studies on buccal. Eudragit rl 100 polymer was weighed accurately and dissolved in ethanol to prepare 10%wv. Mucoadhesive strength of all fabricated buccal patches was measured ex vivo n 3 on a modified physical balance using the method described by gupta et al. Development and evaluation of mucoadhesive buccal patches of. However, buccal patch offer greater flexibility and comfort than circumvent the problem of the relatively short. The ex vivo mucoadhesion time of patches ranged between 109 min fa10 to 126 min fb14. Reserviour type the buccal patch designed in a reservoir system contains a cavity for the drug and additives separate from the adhesive. Bidirectional patches release drug in both the mucosa and the mouth. Buccal mucoadhesive dosage forms three types based on their geometry single layer device with multidirectional releasetypel. Pdf mucoadhesive buccal patches of salbutamol sulphate were prepared using five different polymers polyvinylpyrrolidone pvp, polyvinyl alcohol. Patel nagar, dehradun, uttarakhand248001, india the objective of this study was to develop mucoadhesive buccal tablets of simvastatin using mucoadhesive polymers.
Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. The patches were evaluated with respect to their in vitro drug release, mucoadhesive strength, folding endurance, buccal residence time, convenient. Jun 06, 20 bilayer nct mucoadhesive patches were prepared and evaluated by obaidat et al. Pdf mucoadhesive bilayer buccal patches of verapamil. New insight into the fabrication of smart mucoadhesive. Formulation and evaluation of buccal patches of simvastatin. Formulation and evaluation of mucoadhesive buccal patch of. The purpose of this study was to develop and optimize formulations of mucoadhesive bilayered buccal patches of sumatriptan succinate using chitosan as the base matrix. Buccal mucoadhesive tablets are dry placing in contact with buccal mucosa. Formulation and evaluation of buccal patches of diclofenac sodium. Mucoadhesive bilayered buccal patches of vph may have enhanced bioavailability.
Solvent mixture is the mixture of methanol and dichloromethane. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy. Evaluation of a mucoadhesive buccal patch for delivery of. This article describes buccal permeation of chlorpheniramine maleate cpm and its transbuccal delivery using mucoadhesive buccal patches. Buccal mucosa is robust and mucosa is immobile so ideal for retentive dosage forms. The formulations were tested for in vitro drug permeation studies, buccal absorption test, in vitro release studies, moisture. The reported mucoadhesive buccal patches drug delivery system are summarized here. Formulation and evaluation of mucoadhesive buccal films of. Formulation and evaluation of mucoadhesive buccal films of enalapril maleate a. Formulation and evaluation of buccal patches of simvastatin by using different polymers shalini mishra1, g. Formulation and evaluation of buccal patches for delivery of. The mucoadhesive buccal films of ranitidine were prepared by solvent casting technique using polymers like hydroxyl propyl methyl cellulose e15 hpmc e15 and carbopol 934p alone or in combination.
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